Journal article

The effect of anticoagulants on oral squamous cell carcinoma: A systematic review

Zichen Lin, Li-Qiao R Ling, Mabel Ng, Laith Matlub, Kunal Mehta, Roshine A Linus, Mitchell J Looker, Yovita Melia, Junhan Loong, Rita Paolini, Camile S Farah, Antonio Celentano

Journal of Oral Pathology and Medicine | WILEY | Published : 2020


Tumour progression allows for aberrant angiogenesis. Consequently, cancer-associated thrombosis is a prevalent complication that is coupled with poor prognosis. Anticoagulants have therefore been prescribed with chemotherapeutic agents to target potential thrombo-embolic risk. A systematic review was carried out to summarise existing evidence on the interactions between anticoagulants and oral cancer. This treatment paradigm has demonstrated beneficial results in some oncology patients, thus associating anticoagulants with anticancer effects. Increasing prevalence of oral cancer presents a need to source alternative therapeutic means to prevent disease progression, and thus the use of antico..

View full abstract


Funding Acknowledgements

The authors gratefully acknowledge the support of the Melbourne Dental School, The University of Melbourne. Special thanks to Dr Jim Berryman, Liaison Librarian of Brownless Biomedical Library, University of Melbourne, for his assistance and guidance in forming our search strategy.