Journal article

Bile Acid Signal Molecules Associate Temporally with Respiratory Inflammation and Microbiome Signatures in Clinically Stable Cystic Fibrosis Patients

Stephanie Flynn, F Jerry Reen, Jose A Caparros-Martin, David F Woods, Jorg Peplies, Sarath C Ranganathan, Stephen M Stick, Fergal O'Gara

Microorganisms | MDPI | Published : 2020

Abstract

Cystic fibrosis (CF) is a congenital disorder resulting in a multisystemic impairment in ion homeostasis. The subsequent alteration of electrochemical gradients severely compromises the function of the airway epithelia. These functional changes are accompanied by recurrent cycles of inflammation-infection that progressively lead to pulmonary insufficiency. Recent developments have pointed to the existence of a gut-lung axis connection, which may modulate the progression of lung disease. Molecular signals governing the interplay between these two organs are therefore candidate molecules requiring further clinical evaluation as potential biomarkers. We demonstrate a temporal association betwee..

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Grants

Awarded by European Commission


Awarded by Irish Research Council for Science, Engineering and Technology


Awarded by Science Foundation Ireland


Awarded by Health Research Board/Irish Thoracic Society


Awarded by U.S. CF Foundation


Awarded by Australian NHMRC


Awarded by Marine Institute


Funding Acknowledgements

This research was supported in part by grants awarded by the European Commission (EU-634486-INMARE), The Irish Research Council for Science, Engineering and Technology (GOIPG/2014/647 IRCSET), Science Foundation Ireland (SSPC3-Pharm5: & 15/TIDA/2977), Health Research Board/Irish Thoracic Society (MRCG-2014-6 and MRCG-2018-16) and HRB-ILP-POR-2019-004, The Marine Institute (Beaufort award C2CRA 2007/082), The Glenn Brown Memorial Grant 2017 (The Institute for Respiratory Health, Perth, Australia), U.S. CF Foundation (Grant CFF 1710) and Australian NHMRC 2020-(Synergy APP1183640). S.M.S. is a National Health and Medical Research Council Practitioner Fellow.