Journal article

The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia

Kamala Thriemer, Jeanne-Rini Poespoprodjo, Enny Kenangalem, Nicholas M Douglas, Paulus Sugiarto, Nicholas M Anstey, Julie Anne Simpson, Ric N Price

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

The widespread use of primaquine (PQ) radical cure for P. vivax, is constrained by concerns over its safety. We used routinely collected patient data to compare the overall morbidity and mortality in patients treated with and without PQ without prior testing of Glucose-6-Phosphate-Dehydrogenase (G6PD) deficiency in Papua, Indonesia, where there is a low prevalence of G6PD deficiency. Records were collated from patients older than 1 year, with P. vivax infection, who were treated with an artemisinin combination therapy (ACT). The risks of re-presentation, hospitalization, major fall in haemoglobin and death within 30 days were quantified and compared between patients treated with and without ..

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Grants

Awarded by Wellcome Trust


Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Australian Centre for Research Excellence in Malaria Elimination - NHMRC


Funding Acknowledgements

The study was funded by the Wellcome Trust Senior Fellowship in Clinical Science to RNP (200909) and Training fellowship in Tropical Medicine to JRP (099875). KT is funded through a CSL Centenary Fellowship, NMD was funded by the Rhodes Trust. JAS and NMA are supported by Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowships (1104975, 1135820). The Timika Research Facility and Papuan Community Health Foundation are supported by the Australian Department of Foreign Affairs and Trade (DFAT). This work is supported in part by the Australian Centre for Research Excellence in Malaria Elimination, funded by the NHMRC (1134989). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.We acknowledge the support of staff at Lembaga Pengembangan Masyarakat Amungme Kamoro and Mitra Masyarakat Hospital (RSMM) in Timika, Papua, Indonesia. We also thank Professor Yati Soenarto and Dr. Yodi Mahendradhata from the Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Yogyakarta for their excellent support to the study.