Platinum accumulation in the brain and alteration in the central regulation of cardiovascular and respiratory functions in oxaliplatin-treated rats
Ahmed A Rahman, Vanesa Stojanovska, Paul Pilowsky, Kulmira Nurgali
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | SPRINGER HEIDELBERG | Published : 2020
Oxaliplatin is a platinum-based alkylating chemotherapeutic agent used for cancer treatment. Neurotoxicity is one of its major adverse effects that often demands dose limitation. However, the effects of chronic oxaliplatin on the toxicity of the autonomic nervous system regulating cardiorespiratory function and adaptive reflexes are unknown. Male Sprague Dawley rats were treated with intraperitoneal oxaliplatin (3 mg kg-1 per dose) 3 times a week for 14 days. The effects of chronic oxaliplatin treatment on baseline mean arterial pressure (MAP); heart rate (HR); splanchnic sympathetic nerve activity (sSNA); phrenic nerve activity (PNA) and its amplitude (PNamp) and frequency (PNf); and sympat..View full abstract
This work was supported by a research support grant from Victoria University. KN and AAR obtained funding.