Personalized, Mechanically Strong, and Biodegradable Coronary Artery Stents via Melt Electrowriting
Katarzyna Somszor, Onur Bas, Fatemeh Karimi, Tara Shabab, Navid T Saidy, Andrea J O'Connor, Amanda Ellis, Dietmar Hutmacher, Daniel E Heath
ACS MACRO LETTERS | AMER CHEMICAL SOC | Published : 2020
Biodegradable coronary artery stents are sought-after alternatives to permanent stents. These devices are designed to degrade after the blood vessel heals, leaving behind a regenerated artery. The original generation of clinically available biodegradable stents required significantly thicker struts (∼150 μm) than nondegradable ones to ensure sufficient mechanical strength. However, these thicker struts proved to be a key contributor to the clinical failure of the stents. A current challenge lies in the fabrication of stents that possess both thin struts and adequate mechanical strength. In this contribution, we describe a method for the bottom-up, additive manufacturing of biodegradable comp..View full abstract
Awarded by Australian Research Council (ARC)
K.S. gratefully acknowledges the support of the University of Melbourne and an Australian Government Research Training Program Scholarship (Melbourne International Research Scholarship).This work was funded in part by the Australian Research Council (ARC IC160100026 Industrial Transformation Training Centre in Additive Biomanufacturing), as well as Queensland University of Technology's Institute of Heath and Biomedical Innovation (Innovation Ideas Grant). We also thank the Materials Characterization and Fabrication Platform (the University of Melbourne) for access to infrastructure and equipment.