Alterations in Epithelial Cell Polarity During Endometrial Receptivity: A Systematic Review
Sarah Whitby, Wei Zhou, Evdokia Dimitriadis
Frontiers in Endocrinology | FRONTIERS MEDIA SA | Published : 2020
Background: Abnormal endometrial receptivity is one of the major causes of embryo implantation failure and infertility. The plasma membrane transformation (PMT) describes the collective morphological and molecular alterations occurring to the endometrial luminal epithelium across the mid-secretory phase of the menstrual cycle to facilitate implantation. Dysregulation of this process directly affects endometrial receptivity and implantation. Multiple parallels between these alterations to confer endometrial receptivity in women have been drawn to those seen during the epithelial-mesenchymal transition (EMT) in tumorigenesis. Understanding these similarities and differences will improve our kn..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by a project grant (APP1120689) and a senior research fellowship (#550905) from the National Health and Medical Research Council (NHMRC) of Australia to ED.