Association of β-Amyloid Level, Clinical Progression, and Longitudinal Cognitive Change in Normal Older Individuals

LM Van Der Kall; T Truong; SC Burnham; V Doré; RS Mulligan; S Bozinovski; F Lamb; P Bourgeat; J Fripp; S Schultz; YY Lim; SM Laws; D Ames; C Fowler; SR Rainey-Smith; RN Martins; O Salvado; J Robertson; P Maruff; CL Masters; VL Villemagne; CC Rowe

Journal article

Association of β-Amyloid Level, Clinical Progression, and Longitudinal Cognitive Change in Normal Older Individuals

LM Van Der Kall, T Truong, SC Burnham, V Doré, RS Mulligan, S Bozinovski, F Lamb, P Bourgeat, J Fripp, S Schultz, YY Lim, SM Laws, D Ames, C Fowler, SR Rainey-Smith, RN Martins, O Salvado, J Robertson, P Maruff, CL Masters Show all

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021

DOI: 10.1212/WNL.0000000000011222

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Abstract

ObjectiveTo determine the effect of β-amyloid (Aβ) level on progression risk to mild cognitive impairment (MCI) or dementia and longitudinal cognitive change in cognitively normal (CN) older individuals.MethodsAll CN from the Australian Imaging Biomarkers and Lifestyle study with Aβ PET and ≥3 years follow-up were included (n = 534; age 72 ± 6 years; 27% Aβ positive; follow-up 5.3 ± 1.7 years). Aβ level was divided using the standardized 0-100 Centiloid scale: 100 CL very high, noting >25 CL approximates a positive scan. Cox proportional hazards analysis and linear mixed effect models were used to assess risk of progression and cognitive decline.ResultsAβ levels in 63% were negative, 10% unc..

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University of Melbourne Researchers

David Ames Author

Paul Maruff Author

Victor Villemagne Author

Christopher Rowe Author

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Awarded by Science and Industry Endowment Fund

Funding Acknowledgements

Core funding for the study was provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund in partnership with Austin Health, University of Melbourne, Edith Cowan University, Florey Institute of Neuroscience and Mental Health, Alzheimer's Australia, and the National Ageing Research Institute. The study also received funding from the National Health and Medical Research Council, the Dementia Collaborative Research Centres program, the McCusker Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria.