Sero-epidemiological evaluation of malaria transmission in The Gambia before and after mass drug administration
Lindsey Wu, Julia Mwesigwa, Muna Affara, Mamadou Bah, Simon Correa, Tom Hall, Susheel K Singh, James G Beeson, Kevin KA Tetteh, Immo Kleinschmidt, Umberto D'Alessandro, Chris Drakeley
BMC Medicine | BMC | Published : 2020
BACKGROUND: As The Gambia aims to achieve malaria elimination by 2030, serological assays are a useful surveillance tool to monitor trends in malaria incidence and evaluate community-based interventions. METHODS: Within a mass drug administration (MDA) study in The Gambia, where reduced malaria infection and clinical disease were observed after the intervention, a serological sub-study was conducted in four study villages. Spatio-temporal variation in transmission was measured with a panel of recombinant Pf antigens on a multiplexed bead-based assay. Village-level antibody levels were quantified as under-15 sero-prevalence, sero-conversion rates, and age-adjusted antibody acquisition rates. ..View full abstract
Awarded by UK Medical Research Council (UKMRC) through the LSHTM Doctoral Training Programme studentship
Awarded by National Health and Medical Research Council of Australia
This study was funded by the UK Medical Research Council (UKMRC) through the LSHTM Doctoral Training Programme studentship received by LW (MR/J003999/1). JGB was supported by the National Health and Medical Research Council of Australia (Investigator Grant 1173046, Program Grant 1092789). Burnet Institute is supported by the NHMRC Independent Research Institute Infrastructure Support Scheme and a Victorian State Government Operational Infrastructure grant. The funders had no role in the design of the study; collection, analysis, and interpretation of data; or writing of the manuscript.