Increased episcleral venous pressure in a mouse model of circumlimbal suture induced ocular hypertension
Vickie HY Wong, Da Zhao, Bang Bui, Cameron J Millar, Christine TO Nguyen
EXPERIMENTAL EYE RESEARCH | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2021
PURPOSE: To investigate changes in aqueous humor dynamics during intraocular pressure (IOP) elevation induced by circumlimbal suture in mice. METHODS: Ocular hypertension (OHT) was induced by applying a circumlimbal suture behind the limbus in male adult C57BL6/J mice. In the OHT group, the suture was left in place for an average of 8 weeks (n = 10, OHT group). In the sham control group the suture was cut at 2 days (n = 9, sham group) and in the naïve control group (n = 5) no suture was implanted. IOP was measured at baseline across 3 days, 1 h post-suture implantation, and at the chronic endpoint. Anterior segments were assessed using optical coherence tomography (OCT). Episcleral venous pr..View full abstract
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Awarded by Australian Research Council
Australian Research Council Linkage Grant LP160100126 (C. T. Nguyen, B. V. Bui), Melbourne Research Fellowships (C.T. Nguyen).