Journal article

Brachial-cuff excess pressure is associated with carotid intima-media thickness among Australian children: a cross-sectional population study

Xiaoqing Peng, Dean S Picone, Martin G Schultz, Guoqi Cai, Melissa Wake, David P Burgner, Jonathan P Mynard, Susan Ellul, Michael Cheung, Markus Juonala, James E Sharman

Hypertension Research | SPRINGERNATURE | Published : 2020

Abstract

Reservoir pressure parameters (i.e., reservoir pressure [RP] and excess pressure [XSP]) independently predict cardiovascular events in adults, but this has not been investigated in children. This study aimed to determine (1) the association of reservoir pressure parameters with carotid intima-media thickness (carotid IMT), a preclinical vascular phenotype, and (2) whether a multivariable regression model with or without reservoir pressure parameters fits better for estimating carotid IMT in children. Study participants were 11-12-year-old children (n = 1231, 50% male) from the Child Health CheckPoint study, a cross-sectional substudy of the population-based Longitudinal Study of Australian C..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Funding Acknowledgements

To date, this work has been supported by the National Health and Medical Research Council of Australia (1041352, 1109355), the Royal Children's Hospital Foundation (2014-241), the Murdoch Children's Research Institute, the University of Melbourne, the National Heart Foundation of Australia (100660), and the Financial Markets Foundation for Children (2014-055). The funding bodies played did not play any role in the study. The following authors were supported by the National Health and Medical Research Council of Australia: Early Career Fellowship (1104731) to MGS, R.D. Wright Career Development Fellowship (1143510) to JM, Senior Research Fellowships (1046518) to MW and (1064629, 1175744) to DPB, and Career Development Fellowship (reference 409940) to JS. MW was also supported by Cure Kids, New Zealand, and DB and JM were also supported by the Future Leader Fellowship of the National Heart Foundation of Australia (100369 and 101866). MJ was supported by the Federal Research Grant of Finland to Turku University Hospital, Finnish Cardiovascular Foundation. This article uses unit record data from the LSAC. The study is conducted in partnership between the Department of Social Services (DSS), the Australian Institute of Family Studies (AIFS), and the Australian Bureau of Statistics (ABS). The findings and views reported in this article are those of the author and should not be attributed to DSS, AIFS, or the ABS. We are also grateful to Mr. Xun Yang, HeFei University of Technology, China for providing some technical assistance.