Journal article

Assessing maternal clotting function with novel global coagulation assays: A prospective pilot study

David O'Keefe, Hui Yin Lim, Johnathan Tham, Prahlad Ho, Lisa Hui

International Journal of Laboratory Hematology | WILEY | Published : 2020

Abstract

INTRODUCTION: Women are at higher risk of venous thromboembolism (VTE) during pregnancy and the puerperium. Global coagulation assays (GCAs), including thromboelastography (TEG), thrombin generation using the calibrated automated thrombogram (CAT) and fibrin generation using the overall haemostatic potential assay (OHP), provide a more comprehensive assessment of the coagulation process than conventional coagulation assays. We aimed to evaluate the ability of these GCAs to analyse the coagulability among pregnant women of varying VTE risk profile. METHODS: Women undergoing term elective caesarean delivery provided a single predelivery blood sample for conventional and novel coagulation testi..

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Grants

Funding Acknowledgements

This work was funded by a 2017 Northern Health Small Research Grant, courtesy of the Northern Health Foundation, Epping VIC Australia, and in-kind support from Northern Pathology Victoria.