Brain morphology does not clearly map to cognition in individuals on the bipolar-schizophrenia-spectrum: a cross-diagnostic study of cognitive subgroups
James A Karantonis, Susan L Rossell, Sean P Carruthers, Philip Sumner, Matthew Hughes, Melissa J Green, Christos Pantelis, Katherine E Burdick, Vanessa Cropley, Tamsyn E Van Rheenen
JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2021
BACKGROUND: Characterisation of brain morphological features common to cognitively similar individuals with bipolar disorder (BD) and schizophrenia spectrum disorders (SSD) may be key to understanding their shared neurobiological deficits. In the current study we examined whether three previously characterised cross-diagnostic cognitive subgroups differed among themselves and in comparison to healthy controls across measures of brain morphology. METHOD: T1-weighted structural magnetic resonance imaging scans were obtained for 143 individuals; 65 healthy controls and 78 patients (SSD, n = 40; BD I, n = 38) classified into three cross-diagnostic cognitive subgroups: Globally Impaired (n = 24),..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
Financial support from the National Health and Medical Research Council (NHMRC) provided salary support to TVR (Early Career Fellowship 1088785), SR (Senior Research Fellowship 1154651) and CP (Senior Principal Research Fellowships 628386 and 1105825); and Swinburne University/the Australian Government provided postgraduate scholarships to JK, SC and PS. The authors would also like to acknowledge project specific financial support of the NHMRC (1060664), Henry Freeman Trust, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L Cooper Foundation and the Society of Mental Health Research. Finally, the authors would like to thank the participants in this study for their time and contribution.