Candida albicans steryl 6-O-acyl-alpha-d-mannosides agonize signalling through Mincle
Tram Nguyen, Yuki Hosono, Takashi Shimizu, Sho Yamasaki, Spencer J Williams
Chemical Communications | ROYAL SOC CHEMISTRY | Published : 2020
The C-type lectin receptor Mincle binds Candida albicans and has been implicated in its pathobiology, but the molecular effectors responsible have not been identified. We report the synthesis of cholesteryl and ergosteryl 6-O-acyl-α-d-mannosides, produced by C. albicans mycelium, and demonstrate their ability to signal through human and mouse Mincle.
Related Projects (2)
Awarded by Australian Research Council
Awarded by AMED
We thank the Australian Research Council (DP160100597, DP180101957), the Albert Shimmins Fund, and AMED (JP20gm0910010, JP20ak0101070 and JP20fk0108075).