Candida albicans steryl 6-O-acyl-alpha-d-mannosides agonize signalling through Mincle

Tram Nguyen; Yuki Hosono; Takashi Shimizu; Sho Yamasaki; Spencer J Williams

Journal article

Candida albicans steryl 6-O-acyl-alpha-d-mannosides agonize signalling through Mincle

Tram Nguyen, Yuki Hosono, Takashi Shimizu, Sho Yamasaki, Spencer J Williams

Chemical Communications | ROYAL SOC CHEMISTRY | Published : 2020

DOI: 10.1039/d0cc06263d

Abstract

The C-type lectin receptor Mincle binds Candida albicans and has been implicated in its pathobiology, but the molecular effectors responsible have not been identified. We report the synthesis of cholesteryl and ergosteryl 6-O-acyl-α-d-mannosides, produced by C. albicans mycelium, and demonstrate their ability to signal through human and mouse Mincle.

University of Melbourne Researchers

Spencer Williams Author Chemistry

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Grants

Awarded by Australian Research Council

Awarded by AMED

Funding Acknowledgements

We thank the Australian Research Council (DP160100597, DP180101957), the Albert Shimmins Fund, and AMED (JP20gm0910010, JP20ak0101070 and JP20fk0108075).