Journal article
Cytotoxic T cells swarm by homotypic chemokine signalling
JLG Niño, SV Pageon, SS Tay, F Colakoglu, D Kempe, J Hywood, JK Mazalo, J Cremasco, MA Govendir, LF Dagley, K Hsu, S Rizzetto, J Zieba, G Rice, V Prior, G O’neill, RJ Williams, DR Nisbet, B Kramer, AI Webb Show all
Elife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2020
DOI: 10.7554/eLife.56554
Abstract
Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent of the swarming observed in neutrophils. CTLs engaging cognate targets accelerate the recruitment of distant T cells through long-range homotypic signalling, in part mediated via the diffusion of chemokines CCL3 and CCL4. Newly arriving CTLs augment the chemotactic signal, further accelerating mass recruitment in a positive feedback loop. Activated effector human T cells and chimeric antigen recept..
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Awarded by University of New South Wales
Funding Acknowledgements
NSERC RGPIN 50503-10477 Gregory Rice National Health and Medical Research Council GNT1135687 David R Nisbet University of Sydney Centre for Advanced Food Enginomics Mark N Read EMBL Australia Mate Biro NSERC 50503-10476 Gregory Rice The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.