Cytotoxic T cells swarm by homotypic chemokine signalling
Jorge Luis Galeano Nino, Sophie Pageon, Szun S Tay, Feyza Colakoglu, Daryan Kempe, Jack Hywood, Jessica K Mazalo, James Cremasco, Matt A Govendir, Laura F Dagley, Kenneth Hsu, Simone Rizzetto, Jerzy Zieba, Gregory Rice, Victoria Prior, Geraldine M O'Neill, Richard J Williams, David R Nisbet, Belinda Kramer, Andrew Webb Show all
eLife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2020
Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent of the swarming observed in neutrophils. CTLs engaging cognate targets accelerate the recruitment of distant T cells through long-range homotypic signalling, in part mediated via the diffusion of chemokines CCL3 and CCL4. Newly arriving CTLs augment the chemotactic signal, further accelerating mass recruitment in a positive feedback loop. Activated effector human T cells and chimeric antigen recept..View full abstract
Awarded by NSERC
Awarded by National Health and Medical Research Council
NSERC RGPIN 50503-10477 Gregory RiceNational Health and Medical Research Council GNT1135687 David R NisbetUniversity of Sydney Centre for Advanced Food Enginomics Mark N ReadEMBL Australia Mate BiroNSERC 50503-10476 Gregory RiceThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.