Journal article

Apo AI Nanoparticles Delivered Post Myocardial Infarction Moderate Inflammation

Adele L Richart, Medini Reddy, Mina Khalaji, Alaina L Natoli, Sarah E Heywood, Andrew L Siebel, Graeme L Lancaster, Andrew J Murphy, Andrew L Carey, Brian G Drew, Svetlana A Didichenko, Alexei V Navdaev, Bronwyn A Kingwell

Circulation Research | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

RATIONALE: Decades of research have examined immune-modulatory strategies to protect the heart after an acute myocardial infarction and prevent progression to heart failure but have failed to translate to clinical benefit. OBJECTIVE: To determine anti-inflammatory actions of n-apo AI (Apo AI nanoparticles) that contribute to cardiac tissue recovery after myocardial infarction. METHODS AND RESULTS: Using a preclinical mouse model of myocardial infarction, we demonstrate that a single intravenous bolus of n-apo AI (CSL111, 80 mg/kg) delivered immediately after reperfusion reduced the systemic and cardiac inflammatory response. N-apo AI treatment lowered the number of circulating leukocytes by ..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by CSL Ltd


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (APP103652, B. A. Kingwell; 1059454 B.A. Kingwell); the Operational Infrastructure Support Scheme of the Victorian State Government. CSL Ltd provided partial financial support as well as the n-apo AI (Apo AI nanoparticles; CSL111) to the Baker Institute (B.A. Kingwell and A.L. Richart as named investigators) under a nonrestrictive Materials Transfer Agreement but had no role in either development of study design, data acquisition, or interpretation of data.