First-trimester maternal serum biomarkers and the risk of cerebral palsy
Monique Peris, Susan M Reid, Stephen Dobie, Leo Bonacquisto, Daisy A Shepherd, David J Amor
Developmental Medicine & Child Neurology | WILEY | Published : 2020
AIM: To investigate whether combined first-trimester screening (cFTS) biomarkers are associated with cerebral palsy (CP) and to identify CP characteristics associated with abnormal biomarker levels. METHOD: In this retrospective case-control data linkage study, we matched mothers of 435 singletons with CP from a population register to their cFTS records and selected 10 singleton pregnancy controls per case. We compared mean and abnormal levels (expressed as multiples of the median [MoMs]) of pregnancy-associated plasma protein-A (PAPP-A), beta subunit of human chorionic gonadotrophin (β-hCG), and nuchal translucency between cases and controls and between CP subgroups. RESULTS: Compared with ..View full abstract
Funding for the Victorian Cerebral Palsy Register was gratefully received from The Lorenzo and Pamela Galli Medical Research Trust, the Victorian Department Health and Human Services, and the Royal Children's Hospital Foundation. Infrastructure support was provided by the Victorian Government's Operational Infrastructure Support Program. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.