Perioperative Procalcitonin in Predicting Infection in Children Undergoing Surgical Procedures.
Aarti Bavare, Brian Rissmiller, Sridevi Devaraj, Danielle Guffey, Deepthi Rajapakshe, Howard Weiner, Christopher Caldarone, Lara Shekerdemian
Journal of Surgical Research | Published : 2021
BACKGROUND: Procalcitonin (PCT) is a biomarker of bacterial infections with more sensitivity and specificity than commonly used inflammatory markers. PCT can be particularly helpful in the postsurgical population where the surgery itself often leads to noninfectious inflammation. We aimed to examine the utility of perioperative profiles of PCT in predicting infection in two pediatric surgical populations. METHODS: We conducted a prospective observational study of perioperative PCT in children undergoing cardiac or neurosurgery. Consenting patients with no preoperative infection or immune deficiency were enrolled. We measured plasma PCT levels within 24 h preprocedure and 24-48 h postprocedur..View full abstract