Journal article

Resident Memory T Cells and Their Role within the Liver

Sonia Ghilas, Ana-Maria Valencia-Hernandez, Matthias H Enders, William R Heath, Daniel Fernandez-Ruiz

International Journal of Molecular Sciences | MDPI | Published : 2020


Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses-the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body. They can be broadly separated into circulating memory cells, which pace the entire body through the lymphatics and blood, and tissue-resident memory T (TRM) cells, which are constrained to peripheral tissues. Retained in the tissues where they form, TRM cells provide a frontline defense against reinfection. Here, we review this population of cells wit..

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Awarded by Australian Research Council

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

This work was supported by the Australian Research Council (CE140100011), National Health and Medical Research Council (NHMRC; 1113293 and 1105817) and W-R.H is an NHMRC Senior Principal Research Fellow (1154457).