Microbiome Profiling Reveals Gut Dysbiosis in the Metabotropic Glutamate Receptor 5 Knockout Mouse Model of Schizophrenia
Carolina Gubert, Geraldine Kong, Volkan Uzungil, Ariel M Zeleznikow-Johnston, Emma L Burrows, Thibault Renoir, Anthony J Hannan
Frontiers in Cell and Developmental Biology | FRONTIERS MEDIA SA | Published : 2020
Schizophrenia (SZ) is a psychiatric disorder that constitutes one of the top 10 global causes of disability. More recently, a potential pathogenic role for the gut microbial community (microbiota) has been highlighted, with numerous studies describing dysregulated microbial profiles in SZ patients when compared to healthy controls. However, no animal model of SZ has previously recapitulated the gut dysbiosis observed clinically. Since the metabotropic glutamate receptor 5 (mGlu5) knockout mice provide a preclinical model of SZ with strong face and predictive validity, in the present study we performed gut microbiome profiling of mGlu5 knockout (KO) and wild-type (WT) mice by 16S rRNA sequenc..View full abstract
CG is a recipient of Melbourne Early Career Researcher Award. EB is anNHMRC-ARC Dementia Research Development Fellow. TR is an NHMRC Dementia Fellow. AH is an NHMRC Principal Research Fellow and is also supported by NHMRC Project Grants, an ARC Discovery Project and the DHB Foundation, Equity Trustees.