Journal article

Systematic review and meta-analysis of the role of personality disorder in randomised controlled trials of pharmacological interventions for adults with mood disorders

Bianca E Kavanagh, Melanie M Ashton, Stephanie P Cowdery, Olivia M Dean, Alyna Turner, Michael Berk, Stella M Gwini, Sharon L Brennan-Olsen, Heli Koivumaa-Honkanen, Andrew M Chanen, Lana J Williams

Journal of Affective Disorders | ELSEVIER | Published : 2021

Abstract

BACKGROUND: Personality disorder (PD) may affect the efficacy of pharmacological interventions for mood disorders, but the extent to which this occurs is uncertain. We aimed to examine the available published evidence concerning the role of PD in pharmacological treatment outcomes of randomised controlled trials (RCTs) for adults with mood disorders (i.e. depressive and bipolar spectrum disorders). METHODS: A systematic search of Cochrane Central Register of Controlled Clinical Trials, PubMed, EMBASE, PsycINFO, CINAHL Complete, and Google Scholar databases was undertaken to identify studies of interest. Data were independently extracted by two reviewers. The Cochrane Risk of Bias tool was us..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia Career Development Fellowship


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Investigator grant


Funding Acknowledgements

BEK is supported by an Australian Postgraduate Research Training Scholarship and an Australian Rotary Health Ian Scott PhD Scholarship. MMA is supported by Australian Rotary Health/Ian Parker Bipolar Research Fund PhD scholarship and the Australasian Society for Bipolar and Depressive Disorders/Lundbeck PhD neuroscience scholarship. SPC is supported by a PhD stipend from IMPACT at Deakin University. OMD is supported by a National Health and Medical Research Council (NHMRC) of Australia Career Development Fellowship (1145634). MB is supported by an NHMRC Senior Principal Research Fellowship (1059660 and 1156072). SMG is supported by Barwon Health. SLB-O is supported by an NHMRC Career Development Fellowship (1107510). HK-H is supported by the Paivikki and Sakari Sohlberg Foundation. LJW is supported by an NHMRC Career Development Fellowship (1064272) and a NHMRC Investigator grant (1174060).