Non-invasive fibrosis algorithms are clinically useful for excluding cirrhosis in prisoners living with hepatitis C
Timothy Papaluca, Anne Craigie, Lucy McDonald, Amy Edwards, Michael MacIsaac, Jacinta A Holmes, Matthew Jarman, Tanya Lee, Hannah Huang, Andrew Chan, Mark Lai, Vijaya Sundararajan, Joseph S Doyle, Margaret Hellard, Mark Stoove, Jessica Howell, Paul Desmond, David Iser, Alexander J Thompson
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2020
BACKGROUND AND AIMS: Prison-based HCV treatment rates remain low due to multiple barriers, including accessing transient elastography for cirrhosis determination. The AST-to-platelet ratio index (APRI) and FIB-4 scores have excellent negative predictive value (NPV) in hospital cohorts to exclude cirrhosis. We investigated their performance in a large cohort of prisoners with HCV infection. METHODS: This was a retrospective cohort study of participants assessed by a prison-based hepatitis program. The sensitivity, specificity, NPV and positive predictive value (PPV) of APRI and FIB-4 for cirrhosis were then analysed, with transient elastography as the reference standard. The utility of age th..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
TP received funding from an Australian Government Research Training Program Scholarship and the Department of Gastroenterology, St Vincent's Hospital Melbourne; https://urldefense.com/v3/__https://www.education.gov.au/research-training-program__;!! LUsMDrd6!yF7XCdsDwModOT7ENzQHtsvv3l Aco8amgz6Bf0hZtRF8uM2Os3mbmU1by4H_ 6ApxdVSrzNSo$ AJT and MH received funding from the National Health and Medical Research Council of Australia (NHMRC) Practitioner Fellowships 1142976 and 1112297. https://urldefense.com/v3/__https://www.nhmrc.gov.au/__;!!LUsMDrd6!yF7XCdsDwModOT7ENzQHts vv3lAco8amgz6Bf0hZtRF8uM2Os3mbmU1by4H_ 6ApxdT5HBwwc$ JH is funded by a University of Melbourne CR Roper Fellowship and a NHMRC program grant. https://urldefense.com/v3/__ https://staff.unimelb.edu.au/mdhs/researchdevelopment/research-collaboration-and-funding/faculty-trust-fellowships/cr-roper-fellowship__;!! LUsMDrd6!yF7XCdsDwModOT7ENzQHtsvv3 lAco8amgz6Bf0hZtRF8uM2Os3mbmU1by4H_ 6Apxdbmg15Ep$ This work was supported by NHMRC Program grant 1132902 and Partnership grant 1116161. https://urldefense.com/v3/__ https://www.nhmrc.gov.au/__;!!LUsMDrd6! yF7XCdsDwModOT7ENzQHtsvv3lAco8amgz6Bf0 hZtRF8uM2Os3mbmU1by4H_6ApxdT5HBwwc$ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.