Journal article

Network communication models improve the behavioral and functional predictive utility of the human structural connectome

Caio Seguin, Ye Tian, Andrew Zalesky

Network Neuroscience | MIT PRESS | Published : 2020


The connectome provides the structural substrate facilitating communication between brain regions. We aimed to establish whether accounting for polysynaptic communication in structural connectomes would improve prediction of interindividual variation in behavior as well as increase structure-function coupling strength. Connectomes were mapped for 889 healthy adults participating in the Human Connectome Project. To account for polysynaptic signaling, connectomes were transformed into communication matrices for each of 15 different network communication models. Communication matrices were (a) used to perform predictions of five data-driven behavioral dimensions and (b) correlated to resting-st..

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