Journal article

Effect of liver transplantation on QT-interval prolongation and impact on mortality

Jefferson Ko, Anoop N Koshy, Hui-Chen Han, Laurence Weinberg, Paul Gow, Adam Testro, Han S Lim, Omar Farouque, Andrew W Teh

International Journal of Cardiology | ELSEVIER IRELAND LTD | Published : 2021

Abstract

BACKGROUND: QT-interval prolongation is considered the electrophysiological hallmark of cirrhotic cardiomyopathy. However, the significance of QT-interval prolongation and how it is affected by liver transplantation (LT) remains unclear. METHODS: Consecutive inpatients undergoing LT between 2010 and 2017 at a state-wide liver transplant center in Australia were included. Preoperative, early postoperative and long-term follow-up corrected QT-intervals (QTc) were manually measured by a cardiologist. QTc was calculated using the Bazett formula and QTc ≥440 milliseconds (ms) was considered prolonged. RESULTS: Overall, 1111 ECG tracings among 408 patients (mean age 57 ± 12 years) were assessed. P..

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Grants

Funding Acknowledgements

Dr. Anoop N Koshy is a recipient of the National Health and Medical Research Council of Australia/National Heart Foundation Post-Graduate Scholarship and Royal Australasian College of Physicians Blackburn Scholarship.