Smchd1 is a maternal effect gene required for genomic imprinting
Iromi Wanigasuriya, Quentin Gouil, Sarah A Kinkel, Andres Tapia del Fierro, Tamara Beck, Ellise A Roper, Kelsey Breslin, Jessica Stringer, Karla Hutt, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt
eLife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2020
Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific epigenetic marks. These marks are under the control of maternal effect proteins supplied in the oocyte. Here we report epigenetic repressor Smchd1 as a novel maternal effect gene that regulates the imprinted expression of ten genes in mice. We also found zygotic SMCHD1 had a dose-dependent effect on the imprinted expression of seven genes. Together, zygotic and maternal SMCHD1 regulate three classic imprinted clusters and eight other genes, including non-canonical imprinted genes. Interestingly, the loss of maternal SMCHD1 does not alter germline DNA methylation i..View full abstract
Awarded by National Health and Medical Research Council
National Health and Medical Research Council 1098290 Matthew E Ritchie Marnie E BlewittBellberry-Viertel Senior Medical Research Fellowship Marnie E BlewittThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.