Cirrhotic portal hypertension: From pathophysiology to novel therapeutics
Lakmie S Gunarathne, Harinda Rajapaksha, Nicholas Shackel, Peter W Angus, Chandana B Herath
World Journal of Gastroenterology | BAISHIDENG PUBLISHING GROUP INC | Published : 2020
Portal hypertension and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased intrahepatic vascular resistance and a hyperdynamic circulatory state. The latter is characterized by a high cardiac output, increased total blood volume and splanchnic vasodilatation, resulting in increased mesenteric blood flow. Pharmacological manipulation of cirrhotic portal hypertension targets both the splanchnic and hepatic vascular beds. Drugs such as angiotensin converting enzyme inhibitors and angiotensin II type receptor 1 blockers, which target the components of the classical renin angiotensin system..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Supported by National Health and Medical Research Council (NHMRC) of Australia Project Grants, No. APP1124125.