Journal article

Factors associated with typical enteropathogenic Escherichia coli infection among children < 5 years old with moderate-to-severe diarrhoea in rural western Kenya, 2008-2012

K Fagerli, R Omore, S Kim, JB Ochieng, TL Ayers, J Juma, TH Farag, D Nasrin, S Panchalingam, RM Robins-Browne, JP Nataro, KL Kotloff, MM Levine, J Oundo, MB Parsons, KF Laserson, ED Mintz, RF Breiman, CE O'Reilly

Epidemiology and Infection | CAMBRIDGE UNIV PRESS | Published : 2020

Abstract

Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case..

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Grants

Awarded by Bill & Melinda Gates Foundation


Awarded by Global Enteric Multicenter Study (GEMS)


Funding Acknowledgements

The Bill & Melinda Gates Foundation (www.gatesfoundation.org) funded the Global Enteric Multicenter Study (GEMS) under grants #38874 (GEMS) and #OPP10333572 (GEMS1A) awarded to Principal Investigator MML. The U.S. Agency for International Development provided additional support for technical assistance through an Inter-Agency Agreement with the U.S. Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. All authors had full access to all the data.