Pathophysiological Mechanisms of GASTRO-ESOPHAGEAL Reflux Following Sleeve Gastrectomy.
Yazmin Johari, Gillian Lim, Anagi Wickremasinghe, Helen Yue, Jarrel Seah, Geraldine Ooi, Julie Playfair, Cheryl Laurie, Paul Beech, Kenneth Yap, Geoff Hebbard, Wendy Brown, Paul Burton
Annals of Surgery | Published : 2020
OBJECTIVE: to evaluate the mechanisms associated with reflux events following sleeve gastrectomy (SG). SUMMARY BACKGROUND DATA: Gastro-esophageal reflux (GERD) post-SG is a critical issue due to symptom severity, impact on quality of life, requirement for re-operation, and potential for Barrett's esophagus. The pathophysiology is incompletely delineated. METHODS: Post-SG patients, stratified into asymptomatic and symptomatic, underwent protocolized nuclear scintigraphy (n=83), 24-hour esophageal pH monitoring, and stationary manometry (n=143) to characterize reflux patterns. Ten patients underwent fasting and post-prandial concurrent manometry and pH for detailed analysis of reflux events. R..View full abstract