Journal article

Methods used to meta-analyse results from interrupted time series studies: A methodological systematic review protocol.

Elizabeth Korevaar, Amalia Karahalios, Andrew B Forbes, Simon L Turner, Steve McDonald, Monica Taljaard, Jeremy M Grimshaw, Allen C Cheng, Lisa Bero, Joanne E McKenzie

F1000Research | Published : 2020


Background: Systematic reviews are used to inform healthcare decision making. In reviews that aim to examine the effects of organisational, policy change or public health interventions, or exposures, evidence from interrupted time series (ITS) studies may be included. A core component of many systematic reviews is meta-analysis, which is the statistical synthesis of results across studies. There is currently a lack of guidance informing the choice of meta-analysis methods for combining results from ITS studies, and there have been no studies examining the meta-analysis methods used in practice. This study therefore aims to describe current meta-analysis methods used in a cohort of reviews of..

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