The role of MKK4 in T-cell development and immunity to viral infections
Simon P Preston, Marcel Doerflinger, Hamish W Scott, Cody C Allison, Miles Horton, James Cooney, Marc Pellegrini
Immunology and Cell Biology | WILEY | Published : 2020
The Stress activated protein kinases (SAPKs)/c-Jun-N-terminal-kinases (JNK) are members of the mitogen activated protein kinase (MAPK) family. These kinases are responsible for transducing cellular signals through a phosphorylation dependent signalling cascade. JNK activation in immune cells can lead to a range of critical cellular responses that include proliferation, differentiation and apoptosis. MKK4 is a SAPK that can activate both JNK1 and JNK2; however, its role in T cell development and function has been controversial. Additionally, loss of either JNK1 or JNK2 have opposing effects in the generation of T cell immunity to viral infection and cancer. We used mice with a conditional los..View full abstract
Awarded by National Health and Medical Research Council Australia
This work was supported by National Health and Medical Research Council Australia (Grants 1147010 to MP, 1039014 to SP, 1133538 to JC), The Silvia and Charles Viertel Senior Medical Research Fellowship (MP), the Victorian State Government Operational Infrastructure Support, and the Independent Research Institutes Infrastructure Support Scheme of the Australian Government National Health and Medical Research Council.