Journal article

Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review

Andres Coca-Pelaz, Antti A Makitie, Primoz Strojan, June Corry, Avraham Eisbruch, Jonathan J Beitler, Sandra Nuyts, Robert Smee, Johannes A Langendijk, William M Mendenhall, Cesare Piazza, Alessandra Rinaldo, Alfio Ferlito

Advances in Therapy | SPRINGER | Published : 2020


INTRODUCTION: As a result of the increased use of radiotherapy (RT) and improved long-term overall survival of patients with cancers of the head and neck (HN), the frequency of radiation-induced sarcomas of the head and neck (RISHN) may be increasing. The main objective of this systematic review was to determine the existing evidence on the frequency, treatment, and outcome of RISHN. METHODS: Using PRISMA guidelines we conducted a systematic review of the literature published from 2000 to 2020. RESULTS: Our review includes data of 560 patients from 64 articles. The total frequency of RISHNs among the reviewed series was 0.15%. The most frequent location of the primary tumor treated by RT was..

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University of Melbourne Researchers