Journal article

Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the US

John Epoh Dibato, Olga Montvida, Francesco Zaccardi, Jack Alistair Sargeant, Melanie J Davies, Kamlesh Khunti, Sanjoy K Paul



OBJECTIVE: To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS: From U.S. electronic medical records, 101,104 AA and 505,336 WC subjects with type 2 diabetes diagnosed between 2000 and 2017 were identified (mean follow-up 5.3 years). Among those without ASCVD at diagnosis, risk of ASCVD and three-point major adverse cardiovascular events (MACE-3) (heart failure, myocardial infarction, or stroke) was evaluated between ethnicities by age-groups. RESULTS: The proportion..

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Funding Acknowledgements

Melbourne EpiCentre gratefully acknowledges support from the National Health and Medical Research Council and the Australian Government's National Collaborative Research Infrastructure Strategy initiative through Therapeutic Innovation Australia. The authors acknowledge Dr. Digsu Koye from the University of Melbourne for supporting this research.