Journal article

A potential role for zinc in restless legs syndrome

Pan Chen, Julia Bornhorst, Stephanie Patton, Kanika Bagai, Rachana Nitin, Mahfuzur Miah, Dominic J Hare, Kai Kysenius, Peter J Crouch, Lan Xiong, Guy A Rouleau, Tanja Schwerdtle, James Connor, Michael Aschner, Aaron B Bowman, Arthur S Walters

Sleep | OXFORD UNIV PRESS INC | Published : 2021


STUDY OBJECTIVES: Evaluate serum and brain noniron metals in the pathology and genetics of restless legs syndrome (RLS). METHODS: In two independent studies (cohorts 1 and 2), in which subjects either remained on medications or tapered off medications, we analyzed serum levels of iron, calcium, magnesium, manganese, copper, and zinc both in RLS patients and controls, and assessed the prevalence of the MEIS1 and BTBD9 risk alleles previously established through genome-wide association studies. Human brain sections and a nematode genetic model were also quantified for metal levels using mass spectrometry. RESULTS: We found a significant enrichment for the BTBD9 risk genotype in the RLS affecte..

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University of Melbourne Researchers


Awarded by National Institute of Environmental Health Sciences (NIEHS)

Awarded by ViCTER award

Awarded by German Research Foundation (DFG)

Funding Acknowledgements

This study is supported by the National Institute of Environmental Health Sciences (NIEHS) (grants R01ES10563, NIEHS R01ES07331, and NIEHS R21ES031315), the ViCTER award 3R01ES010563-13S1 and "Manganese levels in patients with Restless Legs Syndrome versus controls." Internal Vanderbilt funding to Dr. Walters"Sleep Research in Neurology." We thank further the German Research Foundation (DFG) for the financial support of the DFG Research Unit TraceAge (FOR 2558).