Journal article

Genetics of methamphetamine use disorder: A systematic review and meta-analyses of gene association studies

Alexandre A Guerin, Eric J Nestler, Michael Berk, Andrew J Lawrence, Susan L Rossell, Jee Hyun Kim

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

Genetic susceptibility to methamphetamine use disorder is poorly understood. No twin or adequately powered genome-wide association studies (GWASs) have been conducted. However, there are a large number of hypothesis-driven candidate gene association studies, which were systematically reviewed herein. Seventy-six studies were identified, investigating markers of 75 different genes. Allele frequencies, odds ratios, 95 % confidence intervals and power were calculated. Risk of bias was also assessed as a quality measure. Meta-analyses were conducted for gene markers if three or more studies were available. Eleven markers from adequately powered studies were significantly associated with methamph..

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Grants

Awarded by National Institutes of Health


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by NHMRC Principal Research Fellowship


Awarded by NHMRC Senior Research Fellowship


Funding Acknowledgements

This work was supported by Melbourne Research Scholarship from the University of Melbourne (AAG); National Institutes of Health GrantP01DA047233 (EJN); NHMRC Senior Principal Research Fellowship1059660 and 1156072 (MB); NHMRC Principal Research Fellowship1116930 (AJL); NHMRC Senior Research Fellowship1154651 (SR); and Brain and Behavior Research Foundation NARSAD young Investigator Award (JHK). We also acknowledge the Victorian State Government Operational Infrastructure Scheme.