Obesity, Akkermansia muciniphila, and Proton Pump Inhibitors: Is there a Link?
Jessica A Davis, Fiona Collier, Mohammadreza Mohebbi, Amanda L Stuart, Amy Loughman, Julie A Pasco, Felice N Jacka
Obesity Research & Clinical Practice | ELSEVIER SCI LTD | Published : 2020
OBJECTIVE: The gut bacterium Akkermansia muciniphila (A. muciniphila), has been linked to body composition and metabolism. However, the role of lifestyle factors and medication use in these relationships has not been considered. This study aimed to assess the relative abundance of A. muciniphila in participants and investigate its association with obesity, with consideration of potential confounding factors. METHODS: Participants included 158 men of the Geelong Osteoporosis Study with dual-energy X-ray absorptiometry data, 16S rRNA gene bacterial profiling of stool samples, and lifestyle data. The relative abundance of A. muciniphila was estimated from total sequence reads, while obesity sta..View full abstract
The authors would like to thank the Geelong Osteoporosis Study participants and staff and acknowledge the support of the Deakin University iMPACT Institute Insti and GCEID teams. We thank Professor Graham Giles of the Cancer Epidemiology Centre of The Cancer Council Victoria, for permission to use the Dietary Questionnaire for Epidemiological Studies (Version 2), Melbourne: The Cancer Council Victoria 1996.