Journal article

Effects of External Stimulators on Engineered Skeletal Muscle Tissue Maturation

Claudia Mueller, Mairon Trujillo-Miranda, Michael Maier, Daniel E Heath, Andrea J O'Connor, Sahar Salehi



Engineering functional skeletal muscle tissue is an ongoing challenge because of the complexity of the in vivo microenvironment and the various factors that contribute to the development and maintenance of the native tissue. However, the growing understanding of the natural skeletal muscle's microenvironment in vivo, as well as the ability to successfully reproduce these factors in vitro, are contributing to the formation of engineered skeletal muscle tissues (SMTs) with greater biomimetic structure and function. This review first summarizes the structure of skeletal muscle tissue. The role of various hydrogels, biomaterials, and scaffolds as building blocks of complex skeletal muscle struct..

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Awarded by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)

Funding Acknowledgements

C.M., M.T.-M., and M.M. contributed equally to this work. This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Projektnummer 326998133 - TRR 225 (subproject B03) and SA 3575/1-1. M.M. gratefully acknowledges support from the University of Melbourne and an Australian Government Research Training Program Scholarship. The authors further acknowledge financial support by the German Academic Exchange service (DAAD) through its Thematic Melbourne-Bayreuth Polymer/Colloid Network sponsored from funds of the Federal Ministry of Education and Research (BMBF).r Open access funding enabled and organized by Projekt DEAL.