Journal article

Influence of blood haemoglobin concentration on renal haemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep

Yugeesh R Lankadeva, Clive N May, Andrew D Cochrane, Bruno Marino, Sally G Hood, Peter R McCall, Nobuki Okazaki, Rinaldo Bellomo, Roger G Evans

ACTA PHYSIOLOGICA | WILEY | Published : 2020


AIM: Blood transfusion may improve renal oxygenation during cardiopulmonary bypass (CPB). In an ovine model of experimental CPB, we tested whether increasing blood haemoglobin concentration [Hb] from ~7 g dL-1 to ~9 g dL-1 improves renal tissue oxygenation. METHODS: Ten sheep were studied while conscious, under stable isoflurane anaesthesia, and during 3 hours of CPB. In a randomized cross-over design, 5 sheep commenced bypass at a high target [Hb], achieved by adding 600 mL donor blood to the priming solution. After 90 minutes of CPB, PlasmaLyte® was added to the blood reservoir to achieve low target [Hb]. For the other 5 sheep, no blood was added to the prime, but after 90 minutes of CPB, ..

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Awarded by National Health and Medical Research Council

Awarded by National Heart Foundation of Australia

Funding Acknowledgements

National Health and Medical Research Council, Grant/Award Number: GNT1122455 and GNT1185777; State Government of Victoria; National Heart Foundation of Australia, Grant/Award Number: 101853