Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI
Madhura Baxi, Maria A Di Biase, Amanda E Lyall, Suheyla Cetin-Karayumak, Johanna Seitz, Lipeng Ning, Nikos Makris, Douglas Rosene, Marek Kubicki, Yogesh Rathi
CEREBRAL CORTEX | OXFORD UNIV PRESS INC | Published : 2020
Early neuroimaging work in twin studies focused on studying genetic and environmental influence on gray matter macrostructure. However, it is also important to understand how gray matter microstructure is influenced by genes and environment to facilitate future investigations of their influence in mental disorders. Advanced diffusion MRI (dMRI) measures allow more accurate assessment of gray matter microstructure compared with conventional diffusion tensor measures. To understand genetic and environmental influence on gray matter, we used diffusion and structural MRI data from a large twin and sibling study (N = 840) and computed advanced dMRI measures including return to origin probability ..View full abstract
Awarded by National Institute on Aging
Awarded by National Institute of Mental Health
We gratefully acknowledge the funding provided by following grants: RO1 AG042512 National Institute on Aging (PI: Dr Marek Kubicki, Dr Nikos Makris and Dr Doug Rosene); R01 MH111917 National Institute of Mental Health (PI: Dr Yogesh Rathi); R01 MH102377 National Institute of Mental Health (PI: Dr Marek Kubicki); R01 MH112748 National Institute of Mental Health (PI: Dr Marek Kubicki and Dr Nikos Makris); R01 MH119222 National Institute of Mental Health (PI: Dr. Yogesh Rathi); K01 MH115247 National Institute of Mental Health (PI: Dr Amanda Lyall); K24 MH110807 National Institute of Mental Health (PI: Dr Marek Kubicki).