Journal article

Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes

Scott T Chiesa, M Loredana Marcovecchio, Paul Benitez-Aguirre, Fergus J Cameron, Maria E Craig, Jennifer J Couper, Elizabeth A Davis, R Neil Dalton, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, John E Deanfield

Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020


An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial and observational cohort study, we characterized the progression of vascular phenotypes throughout this important period and investigated the effect of ACE (angiotensin-converting enzyme) inhibitors and statins in high-risk adolescents. Endothelial function (flow-mediated dilation and reactive hyperemia index) and arterial stiffness (carotid-femoral pulse wave velocity) were assessed in 158 high-risk participants recruited to a randomized, double-blind placebo-control..

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Funding Acknowledgements

AdDIT (Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial) was funded by Diabetes United Kingdom, JDRF International, the British Heart Foundation, JDRF Canada-Canadian Clinical Trial Network, the Canadian Diabetes Association, and the Heart and Stroke Foundation Canada. Pfizer donated the active drugs and the placebos for this trial. The study funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation of the manuscript.