Journal article
One-Pot Synthesis of pH-Responsive Eudragit-Mesoporous Silica Nanocomposites Enable Colonic Delivery of Glucocorticoids for the Treatment of Inflammatory Bowel Disease
Z Qu, KY Wong, M Moniruzzaman, J Begun, HA Santos, SZ Hasnain, T Kumeria, MA McGuckin, A Popat
Advanced Therapeutics | WILEY | Published : 2021
Abstract
Oral glucocorticoids are backbones for the acute management of inflammatory bowel disease (IBD). However, the clinical effectiveness of conventional oral dosage forms of glucocorticoids is hindered by their low delivery efficiency and systemic side effects. To overcome this problem, a smart drug delivery system with high loading capacity and colonic release by coating functionalized mesoporous silica nanoparticles (MSNs) with a pH-responsive polymer Eudragit S100 is proposed. In vitro dissolution tests show that Eudragit-coated MSNs can limit the burst release of loaded prednisolone and budesonide in the gastric environment with more than 60% of the drugs released only at colonic pH (i.e., p..
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Awarded by University of Queensland
Funding Acknowledgements
The authors are thankful for research maintenance funds provided by the School of Pharmacy, The University of Queensland, and the funding provided by the Mater Medical Research Institute. A.P. and T.K. are thankful to the National Health and Medical Research Council of Australia for Career Development (GNT 1146627) and Early Career Fellowship (GNT1143296), respectively. The authors are also thankful to the Centre of Microscopy and Microanalysis (CMM) at UQ and TRI for providing facilities.