Journal article
Chlamydia trachomatis transmission between the oropharynx, urethra and anorectum in men who have sex with men: a mathematical model
Xianglong Xu, Eric PF Chow, Jason J Ong, Christian JPA Hoebe, Zhuoru Zou, Jane S Hocking, Christopher K Fairley, Lei Zhang
BMC Medicine | BMC | Published : 2020
Abstract
BACKGROUND: It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS: To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal sex and calibrated these models to the observed rates of Chlamydia trachomatis infection at three anatomical sites from 4888 men who have sex with men (MSM) in Melbourne Sexual Health Centre during 2018-2019. RESULTS: A model that included only oral and anal sex could replicate the observed rates of single-site infection at the oropharynx, urethra and rectum alone, but could n..
View full abstractGrants
Awarded by Australian National Health and Medical Research Council (NHMRC) Emerging Leadership Investigator Grant
Awarded by Australian NHMRC Leadership Investigator Grant
Awarded by Australian NHMRC Early Career Fellowship
Awarded by National Natural Science Foundation of China
Awarded by Outstanding Young Scholars Funding
Awarded by Xi'an Jiaotong University Basic Research and Profession Grant
Awarded by Xi'an Jiaotong University Young Talent Support Grant
Funding Acknowledgements
EPFC was supported by an Australian National Health and Medical Research Council (NHMRC) Emerging Leadership Investigator Grant (GNT1172873). CKF was supported by an Australian NHMRC Leadership Investigator Grant (GNT1172900). JJO was supported by an Australian NHMRC Early Career Fellowship (APP1104781). LZ was supported by the National Natural Science Foundation of China (Grant number: 8191101420), Outstanding Young Scholars Funding (Grant number: 3111500001), Xi'an Jiaotong University Basic Research and Profession Grant (Grant number: xtr022019003, xzy032020032) and Xi'an Jiaotong University Young Talent Support Grant (Grant number: YX6J004).