Journal article

Chlamydia trachomatis transmission between the oropharynx, urethra and anorectum in men who have sex with men: a mathematical model

Xianglong Xu, Eric PF Chow, Jason J Ong, Christian JPA Hoebe, Zhuoru Zou, Jane S Hocking, Christopher K Fairley, Lei Zhang

BMC Medicine | BMC | Published : 2020

Abstract

BACKGROUND: It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS: To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal sex and calibrated these models to the observed rates of Chlamydia trachomatis infection at three anatomical sites from 4888 men who have sex with men (MSM) in Melbourne Sexual Health Centre during 2018-2019. RESULTS: A model that included only oral and anal sex could replicate the observed rates of single-site infection at the oropharynx, urethra and rectum alone, but could n..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) Emerging Leadership Investigator Grant


Awarded by Australian NHMRC Leadership Investigator Grant


Awarded by Australian NHMRC Early Career Fellowship


Awarded by National Natural Science Foundation of China


Awarded by Outstanding Young Scholars Funding


Awarded by Xi'an Jiaotong University Basic Research and Profession Grant


Awarded by Xi'an Jiaotong University Young Talent Support Grant


Funding Acknowledgements

EPFC was supported by an Australian National Health and Medical Research Council (NHMRC) Emerging Leadership Investigator Grant (GNT1172873). CKF was supported by an Australian NHMRC Leadership Investigator Grant (GNT1172900). JJO was supported by an Australian NHMRC Early Career Fellowship (APP1104781). LZ was supported by the National Natural Science Foundation of China (Grant number: 8191101420), Outstanding Young Scholars Funding (Grant number: 3111500001), Xi'an Jiaotong University Basic Research and Profession Grant (Grant number: xtr022019003, xzy032020032) and Xi'an Jiaotong University Young Talent Support Grant (Grant number: YX6J004).