Journal article

Exposure to adversity and inflammatory outcomes in mid and late childhood

Meredith O'Connor, Anne-Louise Ponsonby, Fiona Collier, Richard Liu, Peter D Sly, Peter Azzopardi, Kate Lycett, Sharon Goldfeld, Sarah J Arnup, David Burgner, Naomi Priest, Peter Vuillermin, Mimi LK Tang, Richard Saffery, John Carlin, Len Harrison

Brain, Behavior, & Immunity - Health | Elsevier BV | Published : 2020

Abstract

Background: We aimed to estimate the association between exposure to adversity and inflammatory markers in mid (4 years) and late (11–12 years) childhood, and whether effects differ by type and timing of exposure. Methods: Data sources: Barwon Infant Study (BIS; N = 510 analyzed) and Longitudinal Study of Australian Children (LSAC; N = 1156 analyzed). Exposures: Adversity indicators assessed from 0 to 4 (BIS) and 0–11 years (LSAC): parent legal problems, mental illness and substance abuse, anger in parenting responses, separation/divorce, unsafe neighborhood, and family member death; a count of adversities; and, in LSAC only, early (0–3), middle (4–7), or later (10–11) initial exposure. Ou..

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