ADORA2A variation and adenosine A(1) receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation
Christa Hohoff, Tina Kroll, Baoyuan Zhao, Nicole Kerkenberg, Ilona Lang, Kathrin Schwarte, David Elmenhorst, Eva-Maria Elmenhorst, Daniel Aeschbach, Weiqi Zhang, Bernhard T Baune, Bernd Neumaier, Andreas Bauer, Juergen Deckert
Translational Psychiatry | SPRINGERNATURE | Published : 2020
Adenosine, its interacting A1 and A2A receptors, and particularly the variant rs5751876 in the A2A gene ADORA2A have been shown to modulate anxiety, arousal, and sleep. In a pilot positron emission tomography (PET) study in healthy male subjects, we suggested an effect of rs5751876 on in vivo brain A1 receptor (A1AR) availability. As female sex and adenosinergic/dopaminergic interaction partners might have an impact on this rs5751876 effect on A1AR availability, we aimed to (1) further investigate the pilot male-based findings in an independent, newly recruited cohort including women and (2) analyze potential modulation of this rs5751876 effect by additional adenosinergic/dopaminergic gene v..View full abstract
Awarded by Deutsche Forschungsgemeinschaft
The excellent technical assistance of Mona-Larissa Ziegler (University of Munster) as well as of Magdalene Vogeling, Sylvia Kohler-Dibowski, Stephanie Krause, Dorothe Krug, Annette von Wachter, Barbara Elghahwagi, Susanne Schaden, Silke Frensch, Elisabeth Theelen, and Lutz Tellmann (all of the Forschungszentrum Julich) is gratefully acknowledged. Further, we thank the department of radiochemistry (INM-5) of Forschungszentrum Julich for the supply of the radioligand. Support for our study was provided by the Deutsche Forschungsgemeinschaft (SFB TRR58 TP A08 and Z02).