Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats
Hidayat Ullah Khan, Khurram Aamir, Patricia Regina Jusuf, Gautam Sethi, Sreenivas Patro Sisinthy, Reena Ghildyal, Aditya Arya
Life Sciences | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021
BACKGROUND: Lipopolysaccharide (LPS) is an endotoxin that leads to inflammation in many organs, including liver. It binds to pattern recognition receptors, that generally recognise pathogen expressed molecules to transduce signals that result in a multifaceted network of intracellular responses ending up in inflammation. Aim In this study, we used lauric acid (LA), a constituent abundantly found in coconut oil to determine its anti-inflammatory role in LPS-induced liver inflammation in Sprague Dawley (SD) rats. METHOD: Male SD rats were divided into five groups (n = 8), injected with LPS and thereafter treated with LA (50 and 100 mg/kg) or vehicle orally for 14 days. After fourteen days of L..View full abstract
Awarded by Taylor's University Malaysia Flagship Research Grant
This study is supported by Taylor's University Malaysia Flagship Research Grant (TUFR/2017/002/01).