Journal article

Association Between Preoperative Benzodiazepine Use and Postoperative Opioid Use and Health Care Costs

Chris A Rishel, Yuting Zhang, Eric C Sun

JAMA Network Open | JAMA Network | Published : 2020

Abstract

Importance The association between preoperative benzodiazepine use and long-term postoperative outcomes is not well understood. Objective To characterize the association between preoperative benzodiazepine use and postoperative opioid use and health care costs. Design, Setting, and Participants In this cohort study, retrospective analysis of private health insurance claims data on 946 561 opioid-naive patients (no opioid prescriptions filled in the year before surgery) throughout the US was conducted. Patients underwent 1 of 11 common surgical procedures between January 1, 2004, and December 31, 2016; data analysis was performed January 9, 2020. Exposures Benzodiazepine use, defined a..

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Grants

Awarded by National Institute of Health Anesthesia Training Grant in Biomedical Research


Awarded by National Institute on Drug Abuse


Funding Acknowledgements

Dr Rishel was supported by funding from the National Institute of Health Anesthesia Training Grant in Biomedical Research (NIH T32 GM089626). Dr Sun was supported by funding from the National Institute on Drug Abuse (grant K08DA042314).