Association Between Preoperative Benzodiazepine Use and Postoperative Opioid Use and Health Care Costs

Abstract

Importance The association between preoperative benzodiazepine use and long-term postoperative outcomes is not well understood. Objective To characterize the association between preoperative benzodiazepine use and postoperative opioid use and health care costs. Design, Setting, and Participants In this cohort study, retrospective analysis of private health insurance claims data on 946 561 opioid-naive patients (no opioid prescriptions filled in the year before surgery) throughout the US was conducted. Patients underwent 1 of 11 common surgical procedures between January 1, 2004, and December 31, 2016; data analysis was performed January 9, 2020. Exposures Benzodiazepine use, defined a..