Photoreceptor Degeneration in Pro23His Transgenic Rats (Line 3) Involves Autophagic and Necroptotic Mechanisms
Kiana Kakavand, Andrew I Jobling, Ursula Greferath, Kirstan A Vessey, Robb U de Iongh, Erica L Fletcher
Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2020
Photoreceptor death contributes to 50% of irreversible vision loss in the western world. Pro23His (P23H) transgenic albino rat strains are widely used models for the most common rhodopsin gene mutation associated with the autosomal dominant form of retinitis pigmentosa. However, the mechanism(s) by which photoreceptor death occurs are not well understood and were the principal aim of this study. We first used electroretinogram recording and optical coherence tomography to confirm the time course of functional and structural loss. Electroretinogram analyses revealed significantly decreased rod photoreceptor (a-wave), bipolar cell (b-wave) and amacrine cell responses (oscillatory potentials) f..View full abstract
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Awarded by National Health and Medical Research Council
This research was funded by grants from the National Health and Medical Research Council (APP#1138253 to EF, KV and APP1061418 to EF, AJ).