Undercarboxylated osteocalcin is associated with vascular function in female older adults but does not influence vascular function in male rabbit carotid artery ex vivo
Alexander Tacey, Cassandra Smith, Mary N Woessner, Paul Chubb, Christopher Neil, Gustavo Duque, Alan Hayes, Anthony Zulli, Itamar Levinger
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2020
BACKGROUND: There are conflicting reports on the association of undercarboxylated osteocalcin (ucOC) in cardiovascular disease development, including endothelial function and hypertension. We tested whether ucOC is related to blood pressure and endothelial function in older adults, and if ucOC directly affects endothelial-mediated vasodilation in the carotid artery of rabbits. METHODS: In older adults, ucOC, blood pressure, pulse wave velocity (PWV) and brachial artery flow-mediated dilation (BAFMD) were measured (n = 38, 26 post-menopausal women and 12 men, mean age 73 ± 0.96). The vasoactivity of the carotid artery was assessed in male New Zealand White rabbits following a four-week normal..View full abstract
This study was supported by funding from the Rebecca Cooper Medical Research Foundation (IL) (https://www.cooperfoundation.org.au/) and the Tom Penrose Community Service Grant (IL) (https://www.essa.org.au/) from Exercise and Sports Science Australia (ESSA). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.