Variation by lineage in serum antibody responses to influenza B virus infections
Yiu Chung Lau, Ranawaka APM Perera, Vicky J Fang, Long Hei Luk, Daniel KW Chu, Peng Wu, Ian G Barr, JS Malik Peiris, Benjamin J Cowling
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2020
Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal community-based cohort study conducted in Hong Kong from 2009-2014 to assess patterns in changes in antibody titers to B/Victoria and B/Yamagata viruses following infections with each lineage. Among 62 PCR-confirmed cases, almost half had undetectable hemagglutination inhibition (HAI) antibody titers to the lineage of infection both pre-infection and post-infection. Among those infected with influenza B..View full abstract
Awarded by Food and Health Bureau of the Hong Kong SAR Government
Awarded by Research Grants Council of the Hong Kong Special Administrative Region, China
This study was funded by the Food and Health Bureau of the Hong Kong SAR Government to the Centre for Health Protection (grant nos. CHP-CE-03, 11100882 and 13120602), and the Research Grants Council of the Hong Kong Special Administrative Region, China (project no. T11-705/14N). The funding bodies had no role in study design, data collection and analysis, preparation of the manuscript, or the decision to publish.