Detection of nasopharyngeal carcinoma in Morocco (North Africa) using a multiplex methylation-specific PCR biomarker assay
Imran Nawaz, Khalid Moumad, Debora Martorelli, Moulay Mustapha Ennaji, Xiaoying Zhou, Zhe Zhang, Riccardo Dolcetti, Meriem Khyatti, Ingemar Ernberg, Li-Fu Hu
Clinical Epigenetics | BMC | Published : 2015
BACKGROUND: Silencing of tumor suppressor genes (TSGs) or activation of oncogenes by, e.g., aberrant promoter methylation, may be early events during carcinogenesis. The methylation status of such genes can be used for early detection of cancer. We are pursuing this approach in our efforts to develop markers for early detection and follow-up of nasopharyngeal carcinoma (NPC). We set out to develop this approach to allow identification of NPC from Morocco and then also compared with NPC samples from different geographical locations and different ethnicity with different NPC incidences, Epstein-Barr virus (EBV) prevalence, and environments. RESULTS: By multiplex methylation-specific PCR (MMSP)..View full abstract
Awarded by Cancerfonden, Cancerforeningen in Stockholm, National Natural Science Foundation of China
Awarded by Associazione Italiana per la Ricerca sul Cancro
This study was supported by grants from Cancerfonden, Cancerforeningen in Stockholm, National Natural Science Foundation of China (No. 81202135), and a fellowship from the Project for the Development of University of Balochistan, Quetta, Pakistan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. "The work was supported by a grant from the Associazione Italiana per la Ricerca sul Cancro, contract 14287 to RD".