Toll-Like Receptor 1/2 and 5 Ligands Enhance the Expression of Cyclin D1 and D3 and Induce Proliferation in Mantle Cell Lymphoma
Katy Mastorci, Elena Muraro, Elisa Pasini, Chiara Furlan, Luca Sigalotti, Marina Cinco, Riccardo Dolcetti, Elisabetta Fratta
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2016
Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin's lymphoma with a still undefined etiology. Several lines of evidence are consistent with the possible involvement of peculiar microenvironmental stimuli sustaining tumor cell growth and survival, as the activation of Toll-like receptors (TLR) 4 and 9. However, little is known about the contribution of other TLRs of pathogenic relevance in the development of MCL. This study reports evidence that MCL cell lines and primary MCL cells express different levels of TLR2 and TLR5, and that their triggering is able to further activate the Akt, MAPK, and NF-κB signaling cascades, known to be altered in MCL cells. This leads to the enhance..View full abstract
Awarded by Associazione Italiana per la Ricerca sul Cancro
This study was supported by a grant from Associazione Italiana per la Ricerca sul Cancro to RD (contract 10301; http://www.airc.it/). KM and EP are fellows of the Fondazione Italiana per la Ricerca sul Cancro (http://www.fondazionefirc.it/). EM was supported by a Fondazione Umberto Veronesi Fellowship (http://www.fondazioneveronesi.it/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.