Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
Riccardo Dolcetti, Antonino Carbone
Infectious Agents and Cancer | Published : 2010
Epstein-Barr virus is pathogenically associated with a well defined group of lymphoid and epithelial tumors in which the virus directly drives transformation of infected cells. Recent evidence however indicates that this virus may infect a subpopulation of tumor cells in patients with chronic lymphocytic leukemia (CLL) and EBV infection has been also associated with Richter transformation in a fraction of cases. We herein review available data suggesting a possible role of EBV as a direct or micro-environmental progression factor in a subset of CLL.